New PDF release: Engineering the human germline : an exploration of the

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By Gregory Stock

ISBN-10: 0195133021

ISBN-13: 9780195133028

This booklet explores the numerous customers, demanding situations and moral questions that encompass the engineering of our reproductive cells. it's an available, three-part exam, relocating from concentrated, sensible exams of the promise and difficulties for this advancing expertise to a bit of brief essays at the implications of our technological skill. additionally integrated is a panel dialogue within which prime scientists, ethicists, and public coverage staff provide voice to their techniques and matters relating to our approaching genetic applied sciences. Many international leaders in those fields, together with Leroy Hood, French Anderson, Mario Capecchi, Daniel Koshland, Michael Rose, Lee Silver, and James Watson, have contributed to this quantity, delivering the fundamental components of the talk over germline engineering. in case you have ever meditated the query: "Would I be prepared to genetically adjust my very own child-to-be, given a secure, trustworthy expertise, delivering a tempting possibility?", this booklet may be an vital advisor

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Additional info for Engineering the human germline : an exploration of the science and ethics of altering the genes we pass to our children

Sample text

There are many different types of human cells—muscle cells, brain cells, and bone cells—each of which carry out distinct functions. These distinct cell types or phenotypes are produced by a chromosomal choreography that specifies the appropriate subset of those 100,000 genes that must be expressed for each cell type to generate its particular functionalities. The Human Genome Project is about two types of maps—genetic and sequence. To construct a genetic map, chromosomal markers, termed genetic markers, are identified across our chromosomes.

13 The sequence map is the ultimate map, because it gives us the information necessary to begin deciphering the human book of life, a task which undoubtedly will take one hundred or more years. If we look back at the Human Genome Project in twenty years, it is apparent that three major benefits will have been achieved. First, we will have determined the periodic table of life. The periodic table of chemical 18 The Realities of Human Germline Engineering elements, which was established in the ninteenth century, revolutionized our understanding of chemistry by providing insights into the fundamental relationship of the elements to one another.

The periodic table of life now being provided by the Human Genome Project will, in the same way, provide the information necessary to gain insights into the fundamental elements of life—the genes and the regulatory machinery that turn genes on at the appropriate time in human development, in the appropriate cells, and express the genes at appropriate concentrations. This periodic table will allow us to take the 100 thousand or so human genes and deconvolule them into their basic building blocks, which are called motifs.

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Engineering the human germline : an exploration of the science and ethics of altering the genes we pass to our children by Gregory Stock

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